摘要
RNA therapeutics have emerged as a powerful platform for the treatment of various diseases. The xRNA group works collaboratively with Disease Area groups to optimize siRNA drugs and extend their use to more therapeutic targets. This Postgraduate will support the structure-activity-relationship investigations of siRNA conjugates, contributing to the development of novel extrahepatic siRNA therapeutics. The ideal candidate will have hands-on experience in cell culture, compound analytics, and molecular biology techniques.
Preferred start date: April
Duration: 12 months
Location: Campus Basel
About the Role
Major accountabilities:
- Conducting cell-based assays to screen and evaluate different siRNA conjugate formats.
- Collaborating with in vivo teams to establish in vitro-in vivo correlation and identify the structure-activity relationship of siRNA therapeutics.
- Collecting, analyzing, and accurately documenting experimental data using an electronic lab book.
- Presenting scientific interpretations and findings in internal meetings.
- Assisting in the automation of cell culture workflows to improve efficiency and reproducibility.
Minimum Requirements:
- Recent Master graduate with a degree in Biotechnology, Biology, Bioengineering, Biochemistry, Pharmaceutical Sciences, or similar
- Proficient in English (written and spoken)
- Good theoretical and practical experience in molecular biology (qPCR, PAGE, Flow cytometry)
- Extensive hands-on experience in cell culture and screening
- Capability of running experiments independently
- Excellent team player
Desirable Requirements:
- Prior experience in the cellular and functional characterization of oligonucleotides
- Experience with 3D cell culture
- Experience with automation in cell culture workflows
- Experience working with primary cells
Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all
individuals. If, because of a medical condition or disability, you need a reasonable
accommodation for any part of the recruitment process, or in order to receive more detailed
information about the essential functions of a position, please send an e-mail to
[email protected] and let us know the nature of your request and your
contact information. Please include the job requisition number in your message
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